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Dihydrocapsaicin

Cat. No. M4513
Dihydrocapsaicin Structure
Size Price Availability Quantity
20mg USD 130  USD130 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Dihydrocapsaicin is a natural capsaicin that is a selective TRPV1 agonist and increases P-Akt levels. Dihydrocapsaicin can enhance hypothermic induced neuroprotection.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 307.43
Formula C18H29NO3
CAS Number 19408-84-5
Purity >98%
Solubility DMSO ≥ 200 mg/mL
Storage 4°C , protect from light , dry , sealed
References

[1] Koushitak De, et al. Dihydrocapsaicin induces translational repression and stress granule through HRI-eIF2α phosphorylation axis

[2] Jinatta Jittiwat, et al. Dihydrocapsaicin effectively mitigates cerebral ischemia-induced pathological changes in vivo, partly via antioxidant and anti-apoptotic pathways

[3] Shaomin Shi, et al. Dihydrocapsaicin Inhibits Cell Proliferation and Metastasis in Melanoma via Down-regulating β-Catenin Pathway

[4] Kesinee Nanok, et al. α-Glucosidase, α-amylase, and tyrosinase inhibitory potential of capsaicin and dihydrocapsaicin

[5] Ji Su Lee, et al. Dihydrocapsaicin Inhibits Epithelial Cell Transformation through Targeting Amino Acid Signaling and c-Fos Expression

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