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Diethyldithiocarbamate sodium

Cat. No. M10217
Diethyldithiocarbamate sodium Structure
Synonym:

DDC

Size Price Availability Quantity
5g USD 27  USD30 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

Sodium diethyldithiocarbamate is an accelerator of the rate of copper cementation. Sodium diethyldithiocarbamate reduces the incidence of HIV infection.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 171.26
Formula C5H10NNaS2
CAS Number 148-18-5
Purity >98.5%
Solubility Water 100 mg/mL
Storage at -20°C
References

Effects of epigallocatechin gallate on diethyldithiocarbamate-induced pancreatic fibrosis in rats
Min Meng, et al. Biol Pharm Bull. 2007 Jun;30(6):1091-6. PMID: 17541159.

Camostat, an oral trypsin inhibitor, reduces pancreatic fibrosis induced by repeated administration of a superoxide dismutase inhibitor in rats
Yasuyuki Emori, et al. J Gastroenterol Hepatol. 2005 Jun;20(6):895-9. PMID: 15946137.

Study on free radicals and pancreatic fibrosis--pancreatic fibrosis induced by repeated injections of superoxide dismutase inhibitor
N Matsumura, et al. Pancreas. 2001 Jan;22(1):53-7. PMID: 11138971.

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Abmole Inhibitor Catalog 2017




Keywords: Diethyldithiocarbamate sodium, DDC supplier, HIV Protease, inhibitors

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