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Dieckol

Cat. No. M19442
Dieckol Structure
Size Price Availability Quantity
1mg USD 220  USD220 In stock
5mg USD 600  USD600 In stock
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Quality Control & Documentation
Biological Activity

Dieckol, is a naturally occurring phlorotannin found in some brown algal species. Dieckol has anti-bacterial, anti-cancer, anti-oxidant, anti-aging, anti-diabetic, neuroprotective actions.

Chemical Information
Molecular Weight 742.55
Formula C36H22O18
CAS Number 88095-77-6
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kyung-A Byun, et al. Nutrients. Dieckol-Attenuated High-Fat Diet Induced Muscle Atrophy by Modulating Muscular Deposition of Lipid Droplets

[2] Shouqiang Zhang, et al. Saudi J Biol Sci. Dieckol exerts anticancer activity in human osteosarcoma (MG-63) cells through the inhibition of PI3K/AKT/mTOR signaling pathway

[3] Ziyao Li, et al. Saudi J Biol Sci. Dieckol attenuates the nociception and inflammatory responses in different nociceptive and inflammatory induced mice model

[4] Durairaj Karthick Rajan, et al. Biomed Pharmacother. Dieckol: a brown algal phlorotannin with biological potential

[5] Jeong-Hyun Yoon, et al. Mar Drugs. Dieckol Ameliorates Aβ Production via PI3K/Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell

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