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Diclofenac Epolamine

Cat. No. M20939
Diclofenac Epolamine Structure

DHEP, DIEP, diclofenac hydroxyethylpyrrolidine

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Biological Activity

Diclofenac Epolamine is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.

Chemical Information
Molecular Weight 411.32
Formula C20H24Cl2N2O3
CAS Number 119623-66-4
Solubility (25°C) DMSO 82 mg/mL
Water 82 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Christopher A Jones, et al. Clin Drug Investig. Safety and Efficacy of the FLECTOR (Diclofenac Epolamine) Topical System in Children with Minor Soft Tissue Injuries: A Phase IV Non-randomized Clinical Trial

[2] K D Rainsford, et al. Curr Med Res Opin. Rationale and evidence for the incorporation of heparin into the diclofenac epolamine medicated plaster

[3] G Affaitati, et al. J Biol Regul Homeost Agents. Diclofenac epolamine topical patch for the treatment of pain

[4] B H McCarberg, et al. Int J Clin Pract. Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury

[5] Birte Petersen, et al. Clin Drug Investig. Diclofenac epolamine (Flector) patch: evidence for topical activity

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Keywords: Diclofenac Epolamine, DHEP, DIEP, diclofenac hydroxyethylpyrrolidine supplier, Immunology/Inflammation, inhibitors, activators

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