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Dibenzylfluorescein

Cat. No. M22214
Dibenzylfluorescein Structure
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Biological Activity

Dibenzylfluorescein

Chemical Information
Molecular Weight 512.6
Formula C34H24O5
CAS Number 97744-44-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Abid H Banday, et al. Anticancer Agents Med Chem. Synthesis, Aromatase Inhibitory, Antiproliferative and Molecular Modeling Studies of Functionally Diverse D-Ring Pregnenolone Pyrazoles

[2] Dong Ho Jung, et al. Evid Based Complement Alternat Med. Assessment of the Aromatase Inhibitory Activity of Ma-Huang-Tang (MHT) and Its Active Compounds

[3] Souta Sugiyama, et al. J Vet Med Sci. Genetic diversity of cytochrome P450 3A with different metabolic activity in domestic cats

[4] Teresa W Tam, et al. Can J Physiol Pharmacol. Cree antidiabetic plant extracts display mechanism-based inactivation of CYP3A4

[5] Yanyan Hong, et al. Biochem Pharmacol. Molecular basis for the interaction of four different classes of substrates and inhibitors with human aromatase

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