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DHED (10β, 17β-dihydroxyestra-1,4-dien-3-one) is an inactive precursor compound that selectively produces estrogen only in the brain. Dhe is converted to 17β -estradiol in the brain by an enzyme expressed only in the central nervous system, but is inert elsewhere in the body. DHED was found to have a neuroprotective effect on rat stroke models and reversed neurological symptoms of estrogen deficiency, such as memory problems in ovariously deficient female rats.
| Molecular Weight | 288.38 |
| Formula | C18H24O3 |
| CAS Number | 549-02-0 |
| Solubility (25°C) | DMSO: 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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