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Dextrose iron

Cat. No. M40796
Dextrose iron Structure
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Biological Activity

Dextrose iron can be used to construct animal models of iron overload.

Chemical Information
Molecular Weight 236.00
Formula C6H12FeO6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Catriona Hilton et al. Int J Obes (Lond). Iron, glucose and fat metabolism and obesity: an intertwined relationship

[2] Jiacong Xiao et al. Life Sci. Quercetin protects against iron overload-induced osteoporosis through activating the Nrf2/HO-1 pathway

[3] Shuqin Du et al. Front Endocrinol (Lausanne). Canagliflozin mitigates ferroptosis and improves myocardial oxidative stress in mice with diabetic cardiomyopathy

[4] Ming Li et al. Chem Biol Interact. Baicalein ameliorates cerebral ischemia-reperfusion injury by inhibiting ferroptosis via regulating GPX4/ACSL4/ACSL3 axis

[5] Jordi Mayneris-Perxachs et al. Nat Rev Endocrinol. The role of iron in host-microbiota crosstalk and its effects on systemic glucose metabolism

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