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Dextran (Mw 150000)

Cat. No. M25540
Dextran (Mw 150000) Structure
Size Price Availability Quantity
5g USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Dextran is a multipurpose branched glucan, which can improve plasma colloid osmotic pressure, increase blood volume, reduce platelet adhesion, inhibit red blood cell aggregation, reduce blood viscosity, reduce peripheral circulation resistance, and unclog microcirculation.

Chemical Information
Molecular Weight 150000
Formula (C6H10O5)n
CAS Number 9004-54-0
Solubility (25°C) Soluble in water
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] S Bhunia, et al. Indian J Physiol Pharmacol. Effect of acute haemodilution on right atrial type-B receptor activity in anaesthetized cats

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