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Dexmedetomidine

Cat. No. M2628
Dexmedetomidine Structure
Size Price Availability Quantity
25mg USD 50  USD50 In stock
50mg USD 80  USD80 In stock
100mg USD 128  USD128 In stock
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Quality Control & Documentation
Biological Activity

Dexmedetomidine is a potent and highly selective α-2 adrenergic receptor agonist with sedative effects.

Product Citations
Chemical Information
Molecular Weight 200.28
Formula C13H16N2
CAS Number 113775-47-6
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] S R Tasbihgou, et al. The role of dexmedetomidine in neurosurgery

[2] Maria C Mondardini, et al. Intranasal dexmedetomidine in pediatrics: update of current knowledge

[3] Clemens R M Barends, et al. Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety

[4] Gillian M Keating. Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting

[5] Joana Afonso, et al. Dexmedetomidine: current role in anesthesia and intensive care

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