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Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. It is a major active metabolite of venlafaxine (#542); brain penetrant; Ki = 40 nM and 122 nM for hSERT and hNET, respectively (weak binding at the hDAT). Inhibition of [3H]5-HT or [3H]NE uptake for the hSERT or hNET produced IC50 values of 47 and 531 nM.
| Molecular Weight | 299.84 |
| Formula | C16H25NO2 · HCl |
| CAS Number | 300827-87-6 |
| Solubility (25°C) | DMSO: ≥20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Richard C Shelton. Serotonin and Norepinephrine Reuptake Inhibitors
[3] Patrick Welsch, et al. Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia
[4] Matthew J Snyder, et al. Treating Painful Diabetic Peripheral Neuropathy: An Update
[5] Michael A Sopko Jr, et al. Desvenlafaxine: another "me too" drug?
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