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Desmopressin Acetate

Cat. No. M9862
Desmopressin Acetate Structure
Synonym:

DDAVP; CAS# 16679-58-6

Size Price Availability Quantity
2mg USD 50  USD50 In stock
5mg USD 97  USD97 In stock
10mg USD 147  USD147 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Desmopressin Acetate  is the synthetic analogue of the antidiuretic hormone arginine vasopressin. Desmopressin works by limiting the amount of water that is eliminated in the urine. Desmopressin binds to V2 receptors in renal collecting ducts, increasing water reabsorption. It also stimulates release of von Willebrand factor from endothelial cells by acting on the V2 receptor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1129.27
Formula C46H64N14O12S2.xC2H4O2
CAS Number 16789-98-3
Purity >98%
Solubility Water 20 mg/mL
Storage at -20°C
References

[1] Massimo Franchini, et al. Blood Coagul Fibrinolysis. The use of desmopressin in mild hemophilia A

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Keywords: Desmopressin Acetate, DDAVP; CAS# 16679-58-6 supplier, inhibitors

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