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Desmopressin Acetate

Cat. No. M11457
Desmopressin Acetate Structure
Size Price Availability Quantity
10mg USD 145  USD145 In stock
25mg USD 250  USD250 In stock
50mg USD 375  USD375 In stock
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Quality Control & Documentation
Biological Activity

Desmopressin is a synthetic octapeptide that is an analogue of the human hormone arginine vasopressin and has antidiuretic and procoagulant effects.

Chemical Information
Molecular Weight 1129.28
Formula C48H68N14O14S2
CAS Number 62288-83-9
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Pamela Galati, et al. J Vet Intern Med. Effects of desmopressin acetate administration in healthy dogs receiving prednisolone

[2] Natasha Alford, et al. Expert Rev Clin Pharmacol. Desmopressin acetate the first sublingual tablet to treat nocturia due to nocturnal polyuria

[3] Cynthia C Lim, et al. Intern Med J. Desmopressin acetate to prevent bleeding in percutaneous kidney biopsy: a systematic review

[4] Joshua A Cohn, et al. Expert Rev Clin Pharmacol. Desmopressin acetate nasal spray for adults with nocturia

[5] Laxminarayan Karanth, et al. Cochrane Database Syst Rev. Desmopressin acetate (DDAVP) for preventing and treating acute bleeds during pregnancy in women with congenital bleeding disorders

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