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Denopamine

Cat. No. M30531

All AbMole products are for research use only, cannot be used for human consumption.

Denopamine Structure
Synonym:

(R)-(-)-Denopamine; TA-064

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Quality Control & Documentation
Biological Activity

Denopamine ((R)-(-)-Denopamine) is an orally active, selective β1-adrenergic agonist. Denopamine prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-α production in the heart. Cardiovascular effects.

Chemical Information
Molecular Weight 317.38
Formula C18H23NO4
CAS Number 71771-90-9
Form Solid
Solubility (25°C) DMSO 5 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hidefumi Kaji, et al. Drug Metab Dispos. Regioselective glucuronidation of denopamine: marked species differences and identification of human udp-glucuronosyltransferase isoform

[2] Takeshi Ishide. Curr Med Res Opin. Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator

[3] T Sakuma, et al. J Appl Physiol (1985). Denopamine, a beta(1)-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs

[4] R Nishio, et al. J Am Coll Cardiol. Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart

[5] Y Sasaki, et al. Biochem Pharmacol. Effect of denopamine on the phosphorylation of cardiac muscle proteins in the perfused guinea-pig heart. Comparison with isoproterenol

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Keywords: Denopamine, (R)-(-)-Denopamine; TA-064 supplier, Adrenergic Receptor, inhibitors, activators

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