Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine has antiviral activity against influenza A virus, IC50 values for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2) were 3.39 μM, 2.16 μM and 5.32 μM, respectively.
Basic Clin Pharmacol Toxicol. 2021 Mar;128(3):379-385.
Dendrobine attenuates gestational diabetes mellitus in mice by inhibiting Th17 cells
Dendrobine purchased from AbMole
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Source | Basic Clin Pharmacol Toxicol (2020), Figure 2, Dendrobine (AbMole Bioscience) |
| Method | orally gavaged | |
| Cell Lines | 10-12-week-old C57BL/KsJ+/+ (wild-type) mice | |
| Concentrations | 20 mg/kg | |
| Incubation Time | 20 days | |
| Results | After 10 days of pregnancy, we performed glucose and insulin tolerance tests again on the same mice and found that, compared with wild-type mice, GDM mice displayed glucose tolerance and insulin resistance, which can be alleviated by dendrobine treatment |
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Source | Basic Clin Pharmacol Toxicol (2020), Figure 1, Dendrobine (AbMole Bioscience) |
| Method | orally gavaged | |
| Cell Lines | 10-12-week-old C57BL/KsJ+/+ (wild-type) mice | |
| Concentrations | 20 mg/kg | |
| Incubation Time | 20 days | |
| Results | Compared with the high and stable serum insulin level in the wild-type mice, the serum insulin level diminished during pregnancy in GDM mice, which was reversed in the GDM + dendrobine group |
| Molecular Weight | 263.38 |
| Formula | C16H25NO2 |
| CAS Number | 2115-91-5 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Mao-Sheng Zhang, et al. Dendrobine-type alkaloids from Dendrobium nobile
[5] Dan Yang, et al. Two unusual dendrobine-type alkaloids from Dendrobium findlayanum
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