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Demeclocycline is an orally active semisynthetic tetracycline antibiotic that affects protein synthesis by binding to the 30S ribosomal subunit, thereby inhibiting the binding of aminoacyl tRNA. It has broad-spectrum antibacterial activity.
| Molecular Weight | 464.85 |
| Formula | C21H21ClN2O8 |
| CAS Number | 127-33-3 |
| Solubility (25°C) | Water 1.5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] A Hayek et al. JAMA. Demeclocycline-induced diabetes insipidus
[5] J R Oster et al. Lancet. Demeclocycline-induced renal failure
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