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Deltamethrin produces a reversible sequence of motor symptoms in rats involving hind limb rigidity and choreoathetosis. The main target of deltamethrin is the basic voltage-gated sodium channel (VGSCs) of nerve cell excitatory conduction. The mechanism of action is to prolong the opening time of VGSCs in insects, so that the cell membrane continues to depolarize, so the symptoms of poisoning after ataxia , that is, immediately convulsed and quickly entered a paralyzed state, and finally paralyzed and died. In addition, deltamethrin can also act on other targets of insects, such as chloride ion channels, ATPase, GABA receptors, glutamate receptors, acetylcholine receptors, and voltage-gated calcium ion channels.
| Molecular Weight | 505.2 |
| Formula | C22H19Br2NO3 |
| CAS Number | 52918-63-5 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Chunrong Xiong, et al. PLoS One. Trypsin-catalyzed deltamethrin degradation
[4] No authors listed. IARC Monogr Eval Carcinog Risks Hum. Deltamethrin
[5] R Mestres, et al. Rev Environ Contam Toxicol. Deltamethrin: uses and environmental safety
| Related Metabolite/Endogenous Metabolite Products |
|---|
| Arachidonic acid sodium salt
Arachidonic acid sodium salt (Sodium Arachidonate) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid sodium salt also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). |
| trans-Vaccenic acid
trans-Vaccenic acid is a naturally occurring trans fatty acid (TFA). trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated Linoleic acid (CLA) at the tissue level. trans-Vaccenic acid inhibits nasopharyngeal carcinoma (NPC) cell growth and induces apoptosis through the inhibition of Bad/Akt phosphorylation. |
| Mead acid
Mead acid (5,8,11-Eicosatrienoic acid) is an unsaturated (Omega-9) fatty acid. |
| p-Cresol glucuronide
p-Cresol glucuronide is a metabolite of p-cresol, it is a prototype protein-bound uremic toxin. |
| Oleamide
Oleamide is an endogenous fatty acid amide. |
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