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Delcasertib hydrochloride

Cat. No. M13858
Delcasertib hydrochloride Structure
Synonym:

KAI-9803 hydrochloride; BMS-875944 hydrochloride

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Quality Control & Documentation
Biological Activity

Delcasertib (KAI-9803) hydrochloride is a potent and selective δ-protein kinase C (δPKC) inhibitor. Delcasertib (KAI-9803) hydrochloride could ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI).

Chemical Information
Molecular Weight 2916.74
Solubility (25°C) Water 90 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] M Bays, et al. Methods Find Exp Clin Pharmacol. Gateways to clinical trials

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Keywords: Delcasertib hydrochloride, KAI-9803 hydrochloride; BMS-875944 hydrochloride supplier, PKC, inhibitors, activators


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