Free shipping on all orders over $ 500

Defensin HNP-3 human

Cat. No. M41025
Defensin HNP-3 human Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Defensin HNP-3 human is a cytotoxic antibiotic peptide known as "defensin".

Chemical Information
Molecular Weight 3486.04
Formula C151H222N44O40S6
CAS Number 136661-76-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nesrin Büyüktortop Gökçınar et al. Ocul Immunol Inflamm. Elevated Tear Human Neutrophil Peptides 1-3, Human Beta Defensin-2 Levels and Conjunctival Cathelicidin LL-37 Gene Expression in Ocular Rosacea

[2] Ambure Sharadadevi et al. J Biomol Struct Dyn. A molecular dynamics study of human defensins HBD-1 and HNP-3 in water

[3] Robert I Lehrer. Curr Opin Hematol. Multispecific myeloid defensins

[4] Jakob Albrethsen et al. BMC Cancer. Upregulated expression of human neutrophil peptides 1, 2 and 3 (HNP 1-3) in colon cancer serum and tumours: a biomarker study

[5] C Goebel et al. Peptides. Determination of defensin HNP-1, HNP-2, and HNP-3 in human saliva by using LC/MS

Related Antibiotic Products
TH-Z145

TH-Z145 is a lipophilic GGPPS inhibitor (GGPPS IC50 = 210 nM). TH-Z145 is a very lipophilic bisphosphonate that lacks the cationic center essential for FPPS inhibition and is thus a specific GGPPS inhibitor (FPPS IC50 >30 mM). TH-Z145 exhibited strong prophylactic effects in a pathogenic influenza model.

TH-Z93

TH-Z93, a lipophilic bisphosphonate, is an FPPS inhibitor (IC50 = 90 nM). TH-Z93 exhibits potent efficacy, increasing both antibody titers and avidity. TH-Z93 exhibited strong prophylactic effects in a pathogenic influenza model.

Ningnanmycin

Ningnanmycin is a cytosine nucleoside peptide antibiotic, which is a highly effective, low-toxic, non-accumulative, broad-spectrum fungicide.

Sulfacytine

Sulfacytine is a short-acting sulfonamide antibiotic.

Cefcapene pivoxil hydrochloride

Cefcapene pivoxil hydrochloride, the pivalate ester precursor form of Cefcapene, is an orally active third-generation cephalosporin with a wide spectrum of anti-bacterial activity. Cefcapene pivoxil hydrochloride has the potential for the palmoplantar pustulosis (PPP) research.

  Catalog
Abmole Inhibitor Catalog




Keywords: Defensin HNP-3 human supplier, Antibiotic, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.