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DDD107498

Cat. No. M20995

All AbMole products are for research use only, cannot be used for human consumption.

DDD107498 Structure
Synonym:

M-5717, DDD-498

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Quality Control & Documentation
Biological Activity

DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.

Chemical Information
Molecular Weight 462.56
Formula C27H31FN4O2
CAS Number 1469439-69-7
Solubility (25°C) DMSO 93 mg/mL
Water 93 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Rupali Shivapurkar, et al. Sci Rep. Evaluating antimalarial efficacy by tracking glycolysis in Plasmodium falciparum using NMR spectroscopy

[2] Patrick Hochegger, et al. Bioorg Med Chem. New derivatives of quinoline-4-carboxylic acid with antiplasmodial activity

[3] Akshaya Srikanth Bhagavathula, et al. Infect Dis Poverty. Alternatives to currently used antimalarial drugs: in search of a magic bullet

[4] Beatriz Baragaa, et al. J Med Chem. Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

[5] Beatriz Baragaa, et al. Nature. A novel multiple-stage antimalarial agent that inhibits protein synthesis

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Keywords: DDD107498, M-5717, DDD-498 supplier, inhibitors, activators

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