Free shipping on all orders over $ 500

DCC2701

Cat. No. M4966
DCC2701 Structure
Synonym:

Altiratinib

Size Price Availability Quantity
10mM*1mL in DMSO USD 48  USD60 In stock
5mg USD 42.4  USD53 In stock
10mg USD 70.4  USD88 In stock
50mg USD 192  USD240 In stock
100mg USD 352  USD440 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Altiratinib(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 510.46
Formula C26H21F3N4O4
CAS Number 1345847-93-9
Purity 99.01%
Solubility DMSO: 33mg/mL
Storage at -20°C
References

[1] Kwon Y,et.al. Oncogene Effective inhibition of c-MET-mediated signaling, growth and migration of ovarian cancer cells is influenced by the ovarian tissue microenvironment.

Related c-Met Products
BAY-474

BAY-474 is an inhibitor of tyrosine-protein kinase c-Met and can act as an epigenetics probe.

AMG-1

AMG-1 (c-Met/RON Dual Kinase Inhibitor, RON-IN-1) is a potent inhibitor of human c-Met and RON with IC50 of 4 nM and 9 nM, respectively.

JNJ-38877618

JNJ-38877618 (OMO-1) is a potent, highly selective, orally bioavailable MET kinase inhibitor with binding affinity (Kd) of 1.4 nM and enzyme inhibitory activity against wt and M1268T mutant MET (2 and 3 nM IC50).

SAR125844

SAR125844 is a potent intravenously active and highly selective MET kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively).

WAY-354831

WAY-354831 is a inhibitor of c-Met kinase.

  Catalog
Abmole Inhibitor Catalog




Keywords: DCC2701, Altiratinib supplier, c-Met, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.