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Cat. No. M4966
DCC2701 Structure


Size Price Availability Quantity
10mM*1mL in DMSO USD 60  USD60 In stock
5mg USD 53  USD53 In stock
10mg USD 88  USD88 In stock
50mg USD 240  USD240 In stock
100mg USD 440  USD440 In stock
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Quality Control & Documentation
Biological Activity

Altiratinib(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro.

Chemical Information
Molecular Weight 510.46
Formula C26H21F3N4O4
CAS Number 1345847-93-9
Solubility (25°C) DMSO: 33mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Kwon Y, Oncogene Effective inhibition of c-MET-mediated signaling, growth and migration of ovarian cancer cells is influenced by the ovarian tissue microenvironment.

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Abmole Inhibitor Catalog

Keywords: DCC2701, Altiratinib supplier, c-Met, inhibitors, activators

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