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Daptomycin (Cubicin) is a novel lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms. Daptomycin is active against Gram-positive bacteria only. It has proven in vitro activity against enterococci (including glycopeptide-resistant Enterococci (GRE)), staphylococci (including methicillin-resistant Staphylococcus aureus), streptococci and corynebacteria. Daptomycin disrupts plasma membrane function, which makes it useful against resistant bacteria. It is thought to cause rapid depolarization thereby inhibiting protein, DNA and RNA synthesis. Daptomycin and nafcillin in combination significantly improved antibacterial activity against VISA.
| Molecular Weight | 1620.67 |
| Formula | C72H101N17O26 |
| CAS Number | 103060-53-3 |
| Solubility (25°C) | Water 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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