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Dantrolene (F368) non-competitively inhibits human erythrocyte glutathione reductase. Ki and IC50 values are 111.6 μM and 52.3 μM, respectively. Dantrolene is a ryanodine receptor antagonist and Ca2+ signaling stabilizer. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.
| Molecular Weight | 314.25 |
| Formula | C14H10N4O5 |
| CAS Number | 7261-97-4 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Li Liang, et al. Alzheimer Dis Assoc Disord. Dantrolene, a treatment for Alzheimer disease?
[4] B A Britt. Can Anaesth Soc J. Dantrolene
[5] J M Campos Suárez, et al. Rev Esp Anestesiol Reanim. [Sodium dantrolene]
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