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Dalpiciclib hydrochloride is an orally active and highly selective CDK4/6 inhibitor with IC50 values of 12.4 nM and 9.9 nM, respectively.Dalpiciclib hydrochloride showed antitumor activity against breast cancer and esophageal squamous cell carcinoma.
| Molecular Weight | 483.01 |
| Formula | C25H31ClN6O2 |
| CAS Number | 2891598-76-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 5 mg/mL |
| Storage | 4°C, dry, sealed |
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| Abemaciclib metabolites M2
Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50 values of 1.2 and 1.3 nM, respectively. |
| CDK9-IN-1
CDK9-IN-1 is a novel, selective CDK9 inhibitor, with an IC50 of 39 nM for CDK9/CycT1, it can be used for the research of HIV infection. |
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| ML 315
ML 315 is a selective dual inhibitor of CDK and DYRK with IC50s of 68 nM and 282 nM, respectively. |
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