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Daidzein-4',7-diglucoside

Cat. No. M40206
Daidzein-4',7-diglucoside Structure
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Biological Activity

Daidzein-4',7-diglucoside is a natural product that can be isolated from Radix puerariae.

Chemical Information
Molecular Weight 578.52
Formula C27H30O14
CAS Number 53681-67-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sainan Li et al. J Sep Sci. Ionic-liquid-based ultrasound-assisted extraction combined with countercurrent chromatography and semipreparative LC for the preparation of monoamine oxidase B inhibitors from Pueraria thomsonii

[2] Ji Hong Oh et al. Biomolecules. Investigating the Systems-Level Effect of Pueraria lobata for Menopause-Related Metabolic Diseases Using an Ovariectomized Rat Model and Network Pharmacological Analysis

[3] Wenjuan Feng et al. Zhongguo Zhong Yao Za Zhi. [Chemical constituents of Ammopiptanthus mongolicus]

[4] W M Keung et al. Proc Natl Acad Sci U S A. Potentiation of the bioavailability of daidzin by an extract of Radix puerariae

[5] S P Zhao et al. Yao Xue Xue Bao. [Quantitative TLC-densitometry of isoflavones in Pueraria lobata (Willd.) Ohwi]

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