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D-Tagatose

Cat. No. M20922
D-Tagatose Structure
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Biological Activity

Monosaccharides

Chemical Information
Molecular Weight 180.16
Formula C6H12O6
CAS Number 87-81-0
Solubility (25°C) DMSO 36 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shota Mayumi, et al. Front Cell Infect Microbiol. Potential of Prebiotic D-Tagatose for Prevention of Oral Disease

[2] Mojmr Such, et al. Carbohydr Res. Synthesis of natural/13C-enriched d-tagatose from natural/13C-enriched d-fructose

[3] Marion Guerrero-Wyss, et al. Biomed Res Int. D-Tagatose Is a Promising Sweetener to Control Glycaemia: A New Functional Food

[4] Khaleque Hasibul, et al. Mol Med Rep. D‑Tagatose inhibits the growth and biofilm formation of Streptococcus mutans

[5] J Jayamuthunagai, et al. Crit Rev Food Sci Nutr. Biocatalytic production of D-tagatose: A potential rare sugar with versatile applications

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