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D-(+)-Malic acid

Cat. No. M19967
D-(+)-Malic acid Structure
Synonym:

D-Malic acid

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500mg USD 50  USD50 In stock
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Biological Activity

D-(+)-Malic acid (D-Malic acid) is an active isomer of Malic acid and a competitive inhibitor of L(-)malic acid transport. D-(+) -malic acid is an L-type malic acid found in apples and many other fruits and plants. Selective α-amino protection reagent for amino acid derivatives. Multifunctional synthetic chiral compounds including κ-opioid receptor agonists, 1α, 25-dihydroxyvitamin D3 analogues and photomycin B were prepared.

Chemical Information
Molecular Weight 134.09
Formula C4H6O5
CAS Number 636-61-3
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage RT, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shaimaa A Muhamed, et al. Oral Dis. Effect of 1% malic acid spray on diabetes mellitus-induced xerostomia: A randomized clinical trial

[2] Mnica Bull, et al. Metabolism. Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure

[3] Feng Guo, et al. Biotechnol Bioeng. Metabolic engineering of Pichia pastoris for malic acid production from methanol

[4] E Gonzlez-Fandos, et al. Poult Sci. Efficacy of malic acid against Listeria monocytogenes attached to poultry skin during refrigerated storage

[5] Y Vasserot, et al. J Appl Microbiol. A study into the role of L-aspartic acid on the metabolism of L-malic acid and D-glucose by Oenococcus oeni

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