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D-Isoleucine

Cat. No. M39802

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D-Isoleucine Structure

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Quality Control & Documentation
Biological Activity

D-Isoleucine ((R)-Isoleucine), an isoleucine stereoisomer, is a selective activator of Asc-1 antiporter, which enhances long-term potentiation at the hippocampal CA1-CA3 via release of endogenous D-serine.

Chemical Information
Molecular Weight 131.17
Formula C6H13NO2
CAS Number 319-78-8
Form Solid
Solubility (25°C) Water 6 mg/mL (ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hironaga Akita et al. Front Microbiol. Artificial Thermostable D-Amino Acid Dehydrogenase: Creation and Application

[2] Hironaga Akita et al. Biotechnol Lett. Spectrophotometric assay of D-isoleucine using an artificially created D-amino acid dehydrogenase

[3] Ian J Clifton et al. Chembiochem. Isopenicillin N synthase binds δ-(L-α-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms

[4] R S Conrad et al. J Bacteriol. D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida

[5] T Yajima et al. Antimicrob Agents Chemother. Biogenetic origin of the D-isoleucine and N-methyl-L-alloisoleucine residues in the actinomycins

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Keywords: D-Isoleucine supplier, inhibitors, activators

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