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CZC24832

Cat. No. M2609
CZC24832 Structure
Size Price Availability Quantity
2mg USD 60  USD60 In stock
5mg USD 102  USD102 In stock
10mg USD 160  USD160 In stock
50mg USD 450  USD450 In stock
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Quality Control & Documentation
Biological Activity

CZC24832 is the first selective PI3Kγ inhibitor with IC50 of 27 nM, with 10-fold selectivity over PI3Kβ and >100-fold selectivity over PI3Kα and PI3Kδ.

Customer Product Validations & Biological Datas
Source Cell Rep (2016). Figure 3. CZC24832
Method western blot
Cell Lines neutrophils
Concentrations 10 μM
Incubation Time 24 h
Results Use of isoform-specific inhibitors, including the PI3Kg-selective AS252424 and CZC24832, suggested that this was due to PI3Kg
Chemical Information
Molecular Weight 364.4
Formula C15H17FN6O2S
CAS Number 1159824-67-5
Solubility (25°C) DMSO 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hyung-Suk Kim, et al. High WHSC1L1 Expression Reduces Survival Rates in Operated Breast Cancer Patients with Decreased CD8+ T Cells: Machine Learning Approach

[2] Ahmed Y Ali, et al. Distinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration

[3] Kathryn Bell, et al. SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitors

[4] Giovanna Bergamini, et al. A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation

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  Catalog
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Keywords: CZC24832 supplier, PI3K, inhibitors, activators


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