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Cyclo[Arg-Gly-Asp-D-Phe-Lys(Cys)]

Cat. No. M21551

All AbMole products are for research use only, cannot be used for human consumption.

Cyclo[Arg-Gly-Asp-D-Phe-Lys(Cys)] Structure
Size Price Availability Quantity
5mg USD 250  USD250 In stock
10mg USD 450  USD450 In stock
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Quality Control & Documentation
Biological Activity

Cyclo[Arg-Gly-Asp-D-Phe-Lys(Cys)] is a peptide that binds to integrins, a type of receptor protein on the surface of cells. It has been used in cancer research for targeting integrin receptors on tumor cells and has been shown to be effective in inhibiting tumor growth. Cyclo[Arg-Gly-Asp-D-Phe-Lys(Cys)] binds to the α2β1 integrin, which is expressed at high levels on the surface of many tumor cells. This binding inhibits cell proliferation and induces apoptosis. Cyclo[Arg-Gly-Asp-D-Phe-Lys(Cys)] has also been shown to be effective in inhibiting angiogenesis, which is the formation of new blood vessels from pre-existing ones.

Chemical Information
Molecular Weight 706.83 g/mol
Formula C30H46N10O8S
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kam Leung. Cyclo(Cys-Arg-Gly-Asp-Cys)-Gly-Lys-Cy5.5

[2] Liang Shan. 177Lu-Labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-Tyr-cyclo(DAB-Arg-cyclo(Cys-Phe- d-Trp-Lys-Thr-Cys))

[3] Liang Shan. 68Ga-Labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-Tyr-cyclo(DAB-Arg-cyclo(Cys-Phe- d-Trp-Lys-Thr-Cys))

[4] Kam Leung. Cyclo(Cys-Asn-Gly-Arg-Cys)-Gly-Lys-Cy5.5

[5] Kam Leung. OG488-Cyclo(Cys-Asn-Gly-Arg-Cys)-Gly-Lys

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Keywords: Cyclo[Arg-Gly-Asp-D-Phe-Lys(Cys)] supplier, Peptides, inhibitors, activators

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