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Cyclandelate

Cat. No. M2544
Cyclandelate Structure
Synonym:

3,5,5-Trimethylcyclohexyl mandelate

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 30  USD30 In stock
500mg USD 48  USD48 In stock
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Quality Control & Documentation
Biological Activity

Cyclandelate is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.

Chemical Information
Molecular Weight 276.37
Formula C17H24O3
CAS Number 456-59-7
Solubility (25°C) DMSO 35 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] T O Hester, et al. Cyclandelate in the management of tinnitus: a randomized, placebo-controlled study

[2] H C Diener, et al. Cyclandelate in the prophylaxis of migraine: a randomized, parallel, double-blind study in comparison with placebo and propranolol. The Study group

[3] W D Gerber, et al. Cyclandelate versus propranolol in the prophylaxis of migraine--a double-blind placebo-controlled study

[4] No authors listed. Br Med J. Cyclandelate

[5] B Middleton, et al. Cyclandelate. An inhibitor of cholesterol esterification

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Keywords: Cyclandelate, 3,5,5-Trimethylcyclohexyl mandelate supplier, inhibitors, activators


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