Cyasterone, a natural EGFR inhibitor, was primarily isolated from Ajuga Decumbens Thunb (Labiatae). Cyasterone showed antiproliferative effects by inducing apoptosis and cell cycle arrest. Cyasterone could be used in studies against human tumors.
Molecular Weight | 520.65 |
Formula | C29H44O8 |
CAS Number | 17086-76-9 |
Form | Solid |
Solubility (25°C) | DMSO ≥ 60 mg/mL |
Storage | 4°C, protect from light, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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