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CVN293 is a selective and brain permeable potassium (K+) ion channel KCNK13 inhibtor with IC50s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia.
| Molecular Weight | 311.27 |
| Formula | C14H10FN7O |
| CAS Number | 2815296-08-1 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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