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CUR61414 specifically binds to, and antagonizes the activity of smoothened (Smo) in the hedgehog signaling pathway. CUR61414 inhibits proliferation and induces apoptosis in tumor cells without affecting non-tumor cells.
| Molecular Weight | 550.69 |
| Formula | C31H42N4O5 |
| CAS Number | 334998-36-6 |
| Solubility (25°C) | DMSO: 2 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Yuriko Katoh, et al. Hedgehog signaling pathway and gastric cancer
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