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CSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC50 value of 5.8 nM.
| Molecular Weight | 505.56 |
| CAS Number | 2375740-98-8 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage | -20°C, protect from light, sealed |
[1] William E Samsa, et al. The crucial p53-dependent oncogenic role of JAB1 in osteosarcoma in vivo
[5] Anita Schlierf, et al. Targeted inhibition of the COP9 signalosome for treatment of cancer
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