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CRT0066854 

Cat. No. M28439

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CRT0066854  Structure

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Quality Control & Documentation
Biological Activity

CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively.

Chemical Information
Molecular Weight 415.55
Formula C24H25N5S
CAS Number 1438881-19-6
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jing Li, et al. FASEB J. Absence of neurotensin attenuates intestinal dysbiosis and inflammation by maintaining Mmp7/α-defensin axis in diet-induced obese mice

[2] Mark Linch, et al. Carcinogenesis. Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids

[3] Svend Kjær, et al. Biochem J. Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes

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  Catalog
Abmole Inhibitor Catalog




Keywords: CRT0066854  supplier, PKC, inhibitors, activators

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