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CPI-1612

Cat. No. M21260

All AbMole products are for research use only, cannot be used for human consumption.

CPI-1612 Structure

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Quality Control & Documentation
Biological Activity

CPI-1612 is a tool compound that appears to be a fairly efficient EP300/CBP histone acetyltransferase (HAT) inhibitor, exhibiting activity in xenograft models with good PK of higher species.

Chemical Information
Molecular Weight 450.53
Formula C27H26N6O
CAS Number 2374971-81-8
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Archana Bommi-Reddy, et al. PLoS One. CREBBP/EP300 acetyltransferase inhibition disrupts FOXA1-bound enhancers to inhibit the proliferation of ER+ breast cancer cells

[2] Ann C Mladek, et al. Neuro Oncol. RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma

[3] Jonathan E Wilson, et al. ACS Med Chem Lett. Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor

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Keywords: CPI-1612 supplier, Histone Acetyltransferase, inhibitors, activators

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