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CP-101,606

Cat. No. M8215

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CP-101,606 Structure

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Quality Control & Documentation
Biological Activity

Traxoprodil (CP-101,606) is a potent noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, selective for the NR2B subunit. It has been shown to be neuroprotective in animal models of brain injury and stroke.

Chemical Information
Molecular Weight 327.42
Formula C20H25NO3
CAS Number 134234-12-1
Solubility (25°C) DMSO: ≥35 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ewa Bromek, et al. The Selective NMDA Receptor GluN2B Subunit Antagonist CP-101,606 with Antidepressant Properties Modulates Cytochrome P450 Expression in the Liver

[2] Ioline D Henter, et al. Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status

[3] Samuel T Wilkinson, et al. A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems

[4] Ioline D Henter, et al. Glutamatergic Modulators in Depression

[5] F Menniti, et al. CP-101,606, a potent neuroprotectant selective for forebrain neurons

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