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Corticotropin-releasing factor (human) (acetate)

Cat. No. M13937
Corticotropin-releasing factor (human) (acetate) Structure
Synonym:

Human CRF acetate; Human corticotropin-releasing factor acetate

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Biological Activity

Corticotropin-releasing factor human acetate (Human CRF acetate) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.

Chemical Information
Molecular Weight 4817.5
Solubility (25°C) Water
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] C C Zouboulis, et al. Macrophage-activating lipopeptide-2 and corticotropin-releasing hormone stimulate the inflammatory signalling in human sebocytes through activation of stearoyl-CoA desaturase and fatty acid desaturase 2

[2] Shin-Ichiro Hagiwara, et al. Gastric corticotropin-releasing factor influences mast cell infiltration in a rat model of functional dyspepsia

[3] Idoia Gamez, et al. Corticorelin acetate, a synthetic corticotropin-releasing factor with preclinical antitumor activity, alone and with bevacizumab, against human brain tumor models

[4] Idoia Gamez, et al. Corticorelin acetate, a synthetic corticotropin-releasing factor with preclinical antitumor activity, alone and with bevacizumab, against human solid tumor models

[5] J W Kasckow, et al. Regulation of corticotropin-releasing factor secretion and synthesis in the human neuroblastoma clones- BE(2)-M17 and BE(2)-C

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Keywords: Corticotropin-releasing factor (human) (acetate), Human CRF acetate; Human corticotropin-releasing factor acetate supplier, CRFR, inhibitors, activators


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