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Coproporphyrin III

Cat. No. M22061
Coproporphyrin III Structure
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Biological Activity

Coproporphyrin III

Chemical Information
Molecular Weight 654.71
Formula C36H38N4O8
CAS Number 14643-66-4
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mikko Neuvonen, et al. Clin Pharmacol Ther. Performance of Plasma Coproporphyrin I and III as OATP1B1 Biomarkers in Humans

[2] Sagnik Chatterjee, et al. J Pharmacol Exp Ther. Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III

[3] Jun Kunikata, et al. Pediatr Int. Developmental characteristics of urinary coproporphyrin I/(I + III) ratio

[4] Jani Anttila, et al. Biochim Biophys Acta. Is coproporphyrin III a copper-acquisition compound in Paracoccus denitrificans?

[5] H J Castro-Mendoza. Adv Exp Med Biol. Xanthine-coproporphyrin III

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