Free shipping on all orders over $ 500

Copanlisib dihydrochloride

Cat. No. M14848
Copanlisib dihydrochloride Structure
Synonym:

BAY 80-6946 dihydrochloride

Size Price Availability Quantity
5mg USD 60  USD60 In stock
10mg USD 90  USD90 In stock
50mg USD 240  USD240 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib dihydrochloride has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib dihydrochloride has superior antitumor activity.

Chemical Information
Molecular Weight 553.44
CAS Number 1402152-13-9
Solubility (25°C) Water 20 mg/mL
DMSO 5 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Iain Simpson. Ther Deliv. An industry update: the latest developments in therapeutic delivery

Related PI3K Products
SNV4818

SNV4818 is a potential best-in-class (best-in-class) mutation-selective PI3K-α inhibitor with excellent selectivity for the H1047X mutant and moderate selectivity for the related E545/542X mutant.

hSMG-1 inhibitor 11j

hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM.

RLY-2608

RLY-2608 is a first-in-class, orally active, selective inhibitor of PI3Ka metabolism.

EDI048

EDI048 is an orally active Cryptosporidium PI4K inhibitor for the research of cryptosporidiosis.

PI3Kδ-IN-13

PI3Kδ-IN-13 is a PI3Kδ inhibitor (IC50=2.6 nM).

  Catalog
Abmole Inhibitor Catalog




Keywords: Copanlisib dihydrochloride, BAY 80-6946 dihydrochloride supplier, PI3K, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.