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Convicine

Cat. No. M43799
Convicine Structure
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Biological Activity

Convicine is a pyrimidine glycoside.

Chemical Information
Molecular Weight 305.24
Formula C10H15N3O8
CAS Number 19286-37-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Aaron C Elkins et al. Molecules. A Simple High-Throughput Method for the Analysis of Vicine and Convicine in Faba Bean

[2] Felix Heinrich et al. Genes (Basel). Identification of Regulatory SNPs Associated with Vicine and Convicine Content of Vicia faba Based on Genotyping by Sequencing Data Using Deep Learning

[3] Carlo Giuseppe Rizzello et al. Sci Rep. Degradation of vicine, convicine and their aglycones during fermentation of faba bean flour

[4] C Burbano et al. Plant Foods Hum Nutr. Variation of favism-inducing factors (vicine, convicine and L-DOPA) during pod development in Vicia faba L

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