Concanamycin A (Folimycin) is a macrolide antibiotic and a specific vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A inhibits acidification of organelles and perforin-mediated cytotoxicity. In the CD8(+) CTL clone, Concanamycin A (CMA) induced a marked DNA fragmentation and nuclear condensation characteristic of apoptosis.
Int J Mol Sci. 2021 Aug 16;22(16):8779.
Autophagy Mediates the Degradation of Plant ESCRT Component FREE1 in Response to Iron Deficiency
Concanamycin A (Folimycin) purchased from AbMole
| Molecular Weight | 866.09 |
| Formula | C46H75NO14 |
| CAS Number | 80890-47-7 |
| Solubility (25°C) | Limited soluble in DMSO |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related ATPase Products |
|---|
| Transdermal Peptide Disulfide
Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) is a 11-amino acid peptide, binds toNa+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. |
| SPAI-1
SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. |
| Prilocaine acetate
Prilocaine acetate, an amino amide, is a Na/K-ATPase inhibitor. |
| Chamigrenol
Chamigrenol is a Na+/K+-ATPase inhibitor with an IC50 value of 15.9 μg/mL. |
| ZW290
ZW290 is a compound to activate brown adipose tissue (BAT) thermogenic function. |
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