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Concanamycin A (Folimycin)

Cat. No. M7737

All AbMole products are for research use only, cannot be used for human consumption.

Concanamycin A (Folimycin) Structure
Synonym:

X 4357B; Folimycin; CMA

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25ug USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Concanamycin A (Folimycin) is a macrolide antibiotic and a specific vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A inhibits acidification of organelles and perforin-mediated cytotoxicity. In the CD8(+) CTL clone, Concanamycin A (CMA) induced a marked DNA fragmentation and nuclear condensation characteristic of apoptosis.

Product Citations
Chemical Information
Molecular Weight 866.09
Formula C46H75NO14
CAS Number 80890-47-7
Solubility (25°C) Limited soluble in DMSO
Storage 2-8°C, dry, sealed
References

[1] K Togashi, et al. Cytotechnology. Concanamycin A, a vacuolar type H(+)-ATPase inhibitor, induces cell death in activated CD8(+) CTL

[2] Sandeepa M Eswarappa, et al. Innate Immun. Folimycin (concanamycin A) inhibits LPS-induced nitric oxide production and reduces surface localization of TLR4 in murine macrophages

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Keywords: Concanamycin A (Folimycin), X 4357B; Folimycin; CMA supplier, ATPase, inhibitors, activators

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