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Collagenase IV

Cat. No. M10177
Collagenase IV Structure
Size Price Availability Quantity
25mg USD 40  USD40 In stock
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Quality Control & Documentation
Biological Activity

Type IV collagenase, ≥125 CDU/mg solid ( CDU = collagen digestion units ) is especially suitable for the digestion of islet tissue.

Chemical Information
CAS Number 9001-12-1
Solubility (25°C) HBSS
Storage 2-8°C, dry, sealed, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hao-Yan Huang, et al. Theranostics. Collagenase IV and clusterin-modified polycaprolactone-polyethylene glycol nanoparticles for penetrating dense tumor tissues

[2] Clarissa Berardo, et al. Eur J Histochem. Isolation of rat hepatocytes for pharmacological studies on metabotropic glutamate receptor (mGluR) subtype 5: a comparison between collagenase I versus collagenase IV

[3] Zong-Mu Dong, et al. Biosens Bioelectron. Amplified QCM biosensor for type IV collagenase based on collagenase-cleavage of gold nanoparticles functionalized peptide

[4] J S Rao, et al. J Neurooncol. Role of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using an in vitro matrigel model

[5] K Tryggvason, et al. Matrix Suppl. 70 K type IV collagenase (gelatinase)

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