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CMF019 

Cat. No. M28632

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CMF019  Structure

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Quality Control & Documentation
Biological Activity

CMF019 is a potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents. Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin.

Chemical Information
Molecular Weight 455.61
Formula C25H33N3O3S
CAS Number 1586787-08-7
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Cai Read, et al. Biochem Pharmacol. Cardiac action of the first G protein biased small molecule apelin agonist

[2] Cai Read, et al. Front Pharmacol. The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo

[3] Santo Anto, et al. J Cardiovasc Pharmacol. Apelin-Induced Relaxation of Coronary Arteries Is Impaired in a Model of Second-Hand Cigarette Smoke Exposure

[4] Lena Trifonov, et al. Med Chem. An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist

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  Catalog
Abmole Inhibitor Catalog




Keywords: CMF019  supplier, inhibitors, activators

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