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CM-579 trihydrochloride

Cat. No. M21486
CM-579 trihydrochloride  Structure
Size Price Availability
5mg USD 250  USD250 1-2 Weeks
10mg USD 390  USD390 1-2 Weeks
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Quality Control & Documentation
Biological Activity

CM-579 trihydrochloride is a dual inhibitor of G9a and DNA methyltransferase (DNMT), with IC50 values of 16 nM and 32 nM, respectively, as first-in-class, reversible. It plays an active role in a variety of cancer cells.

Chemical Information
Molecular Weight 602.04
Formula C29H43Cl3N4O3
CAS Number 1846570-40-8 (free base)
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage 2-8℃, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ayad Eddaoudi, et al. Methods Mol Biol. Flow Cytometric Detection of G0 in Live Cells by Hoechst 33342 and Pyronin Y Staining

[2] Lisa C Crowley, et al. Cold Spring Harb Protoc. Analyzing Cell Death by Nuclear Staining with Hoechst 33342

[3] Jordi Petriz. Curr Protoc Cytom. Flow cytometry of the side population (SP)

[4] Martin Purschke, et al. Photochem Photobiol Sci. Phototoxicity of Hoechst 33342 in time-lapse fluorescence microscopy

[5] M Bays, et al. Methods Find Exp Clin Pharmacol. Gateways to clinical trials

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  Catalog
Abmole Inhibitor Catalog




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