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EBI-2511

Cat. No. M11161
EBI-2511  Structure
Size Price Availability Quantity
10mg USD 270  USD270 In stock
25mg USD 550  USD550 In stock
50mg USD 800  USD800 In stock
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Quality Control & Documentation
Biological Activity

EBI-2511 is an orally active, potent inhibitor of EZH2 in Pfeffiera cells IC50 The value is 6 nM.

Chemical Information
Molecular Weight 576.77
Formula C34H48N4O4
CAS Number 2098546-05-3
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Biao Lu, et al. ACS Med Chem Lett. Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin's Lymphoma

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  Catalog
Abmole Inhibitor Catalog




Keywords: EBI-2511 supplier, Histone Methyltransferase, inhibitors, activators


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