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Clovibactin

Cat. No. M45048

All AbMole products are for research use only, cannot be used for human consumption.

Clovibactin Structure

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Quality Control & Documentation
Biological Activity

Clovibactin, a novel antibiotic isolated from a soil bacterium and also a phenolphthalein condensate, is inhibitory to a wide range of drug-resistant Gram-positive bacteria, specifically inhibiting the membrane-associated steps of N-acetylglucosaminoglycans (GlcNAc) adherence to the cell wall, as well as the synthesis of peptidoglycan (PGN) and wall phosphatidylsulfonic acid (WTA), interfering with the synthesis of the cell wall and leading to cellular lysis.

Chemical Information
Molecular Weight 903.08
Formula C43H70N10O11
CAS Number 2247194-77-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ana M Pérez-Moreno, et al. Allergy. Clovibactin: Discovery and antimicrobial mechanism of action

[2] Xiang Li, et al. Sci Bull (Beijing). Clovibactin: A revolutionary antibiotic unleashing lethal efficacy against pathogens with little drug resistance

[3] Rhythm Shukla, et al. Cell. An antibiotic from an uncultured bacterium binds to an immutable target

[4] Rhythm Shukla, et al. bioRxiv. A new antibiotic from an uncultured bacterium binds to an immutable target

[5] Maj Krumberger, et al. J Org Chem. Synthesis and Stereochemical Determination of the Peptide Antibiotic Novo29

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Keywords: Clovibactin supplier, Antibiotic, inhibitors, activators

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