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Clovibactin, a novel antibiotic isolated from a soil bacterium and also a phenolphthalein condensate, is inhibitory to a wide range of drug-resistant Gram-positive bacteria, specifically inhibiting the membrane-associated steps of N-acetylglucosaminoglycans (GlcNAc) adherence to the cell wall, as well as the synthesis of peptidoglycan (PGN) and wall phosphatidylsulfonic acid (WTA), interfering with the synthesis of the cell wall and leading to cellular lysis.
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Ana M Pérez-Moreno, et al. Allergy. Clovibactin: Discovery and antimicrobial mechanism of action
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