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Clovibactin

Cat. No. M45048
Clovibactin Structure
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Biological Activity

Clovibactin, a novel antibiotic isolated from a soil bacterium and also a phenolphthalein condensate, is inhibitory to a wide range of drug-resistant Gram-positive bacteria, specifically inhibiting the membrane-associated steps of N-acetylglucosaminoglycans (GlcNAc) adherence to the cell wall, as well as the synthesis of peptidoglycan (PGN) and wall phosphatidylsulfonic acid (WTA), interfering with the synthesis of the cell wall and leading to cellular lysis.

Chemical Information
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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  Catalog
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