All AbMole products are for research use only, cannot be used for human consumption.
Clonidine hydrochloride (Catapres) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg. It treats high blood pressure by stimulating α2 receptors in the brain, which decreases cardiac output and peripheral vascular resistance, lowering blood pressure. It has specificity towards the presynaptic α2 receptors in the vasomotor center in the brainstem. This binding decreases presynaptic calcium levels, and inhibits the release of norepinephrine (NE). The net effect is a decrease in sympathetic tone.
| Molecular Weight | 266.5 |
| Formula | C9H9Cl2N3.HCl |
| CAS Number | 4205-91-8 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] M C Houston. Clonidine hydrochloride
[4] M C Houston. Clonidine hydrochloride: review of pharmacologic and clinical aspects
| Related Adrenergic Receptor Products |
|---|
| Indoramin
Indoramin is a selective α1A-adrenoceptor antagonist. |
| Ro 363 hydrochloride
Ro 363 hydrochloride is a potent and highly selective β1-adrenoceptor agonist. Ro 363 hydrochloride is also an effective inotropic stimulant. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility. |
| Phentolamine
Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. |
| Dipivefrin
Dipivefrin is a potent adrenergic agonist. |
| HOKU-81
HOKU-81 (4-Hydroxytulobuterol) is one of the metabolites of Tulobuterol. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
