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Clomifene citrate

Cat. No. M3564
Clomifene citrate Structure
Synonym:

Clomifene citrate

Size Price Availability Quantity
500mg USD 50  USD50 In stock
1g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Clomifene citrate (Serophene) is a selective estrogen receptor modulator. Clomifene citrate (Serophene) increases production of gonadotropins by inhibiting negative feedback on the hypothalamus. Clomifene citrate (Serophene) is used mainly for ovarian stimulation in female infertility due to anovulation (e.g., infertility in polycystic ovary syndrome). Therapeutically, clomifene citrate (Serophene) is given early in the menstrual cycle. Clomifene citrate (Serophene) is typically prescribed beginning on day 1, 3 or 5 and continuing for 5 days. By that time, FSH level is rising steadily, causing development of a few follicles. Follicles in turn produce the estrogen, which circulates in serum. Clomifene acts by inhibiting the action of estrogen on the pituitary.

Chemical Information
Molecular Weight 598.08
Formula C26H28ClNO.C6H8O7
CAS Number 50-41-9
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jingjing Jiang, et al. Therapeutic effects of dimethyldiguanide combined with clomifene citrate in the treatment of polycystic ovary syndrome

[2] Karen M Wheeler, et al. Clomiphene Citrate for the Treatment of Hypogonadism

[3] Nienke S Weiss, et al. Gonadotrophins versus clomifene citrate with or without intrauterine insemination in women with normogonadotropic anovulation and clomifene failure (M-OVIN): a randomised, two-by-two factorial trial

[4] Stefano Palomba, et al. Management strategies for ovulation induction in women with polycystic ovary syndrome and known clomifene citrate resistance

[5] S Bhattacharya, et al. Clomifene citrate or unstimulated intrauterine insemination compared with expectant management for unexplained infertility: pragmatic randomised controlled trial

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