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Clodronate disodium is a first generation (non-nitrogenous) bisphosphonate. Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. Additionally, Clodronate demonstrates the ability to cause a collapse of the mitochondrial membrane potential which eventually results in osteoclast apoptosis. Clodronate is also used in experimental medicine to selectively deplete macrophages.
| Molecular Weight | 288.86 |
| Formula | CH2Cl2O6P2Na2 |
| CAS Number | 22560-50-5 |
| Solubility (25°C) | Water ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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